TP53 germline mutations in adult patients with adrenocortical carcinoma.


CONTEXT Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with germline mutations in TP53. According to the Chompret criteria for LFS, any patient with adrenocortical cancer (ACC), irrespective of age and family history, is at high risk for a TP53 germline mutation. However, whereas such mutations have been detected with high… (More)
DOI: 10.1210/jc.2011-1982


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