TP53 gene polymorphism: Importance to cancer, ethnicity and birth weight in a Brazilian cohort

  title={TP53 gene polymorphism: Importance to cancer, ethnicity and birth weight in a Brazilian cohort},
  author={H. Thurow and R. Haack and F. Hartwig and I. Oliveira and O. Dellagostin and D. Gigante and B. Horta and T. Collares and F. Seixas},
  journal={Journal of Biosciences},
  • H. Thurow, R. Haack, +6 authors F. Seixas
  • Published 2011
  • Medicine, Biology
  • Journal of Biosciences
  • Arg72Pro SNP of p53 has been associated with many types of cancer as well as with survival and longevity. We evaluated the Arg72Pro SNP frequencies of a Brazilian birth cohort and their association with current, demographic and birth epidemiological parameters available. In 1982, all hospital births of Pelotas, southern Brazil, were identified and studied prospectively. In 2004–5, blood samples were collected and DNA extracted. PCR-RFLP was used to genotype the Arg72Pro SNP in 3794 individual… CONTINUE READING
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