TP53 gene polymorphism: Importance to cancer, ethnicity and birth weight in a Brazilian cohort

@article{Thurow2011TP53GP,
  title={TP53 gene polymorphism: Importance to cancer, ethnicity and birth weight in a Brazilian cohort},
  author={Helena Strelow Thurow and Ricardo Lanzetta Haack and Fernando Pires Hartwig and Isabel Oliveira de Oliveira and Odir Ant{\^o}nio Dellagostin and Denise Petrucci Gigante and Bernardo Lessa Horta and Tiago V. Collares and Fabiana K{\"o}mmling Seixas},
  journal={Journal of Biosciences},
  year={2011},
  volume={36},
  pages={823-831}
}
Arg72Pro SNP of p53 has been associated with many types of cancer as well as with survival and longevity. We evaluated the Arg72Pro SNP frequencies of a Brazilian birth cohort and their association with current, demographic and birth epidemiological parameters available. In 1982, all hospital births of Pelotas, southern Brazil, were identified and studied prospectively. In 2004–5, blood samples were collected and DNA extracted. PCR-RFLP was used to genotype the Arg72Pro SNP in 3794 individual… Expand
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References

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Role of TP53 Arg72Pro polymorphism in urinary bladder cancer predisposition and predictive impact of proline related genotype in advanced tumors in an ethnic Kashmiri population.
TLDR
It is evident from this study that Arg72Pro SNP is implicated in bladder cancer, and that the rare, proline-related allele is connected with higher susceptibility to bladder cancer. Expand
Proline homozygosity in codon 72 of p53 is a factor of susceptibility for thyroid cancer.
TLDR
Evidence is provided that p53 polymorphism is implicated in thyroid carcinogenesis and that individuals harboring the Pro/Pro genotype have an increased risk of developing thyroid cancer. Expand
Study of p53 codon 72 polymorphism in various ethnic groups of North India
TLDR
The low prevalence of HPV-related cervical cancer in the Kashmiri population did not seem to affect or be related to the frequency of the presumed susceptibility allele (Arg allele), and the only group, which showed significantly increased Frequency of the Arg/Arg allele, was from Ladakh. Expand
Prognostic significance of p53 codon 72 polymorphism in lung carcinomas.
TLDR
The data suggest that p53 codon 72 polymorphism may be a potential prognostic factor in certain sub groups of lung cancer patients in Taiwan. Expand
Evaluation of p53 codon 72 polymorphism in adenocarcinomas of the colon and rectum in La Plata, Argentina.
TLDR
The findings of the present study indicate that p53 codon 72 arginine homozygous genotype may represent a genetic predisposing factor for colon cancer development, however, further studies are needed in order to elucidate the role of p53codon 72 polymorphism in colorectal cancer. Expand
The association of p53 mutations and p53 codon 72, Her 2 codon 655 and MTHFR C677T polymorphisms with breast cancer in Northern Greece.
TLDR
Results showed that p53 codon 72 polymorphism is statistically significantly associated with breast cancer (OR for Arg/Arg to non-Arg/Arg was 6.66, P = 0.0001 at 95% CI 2.63-16.9), but not Her 2 and MTHFR polymorphisms are associated with Breast cancer. Expand
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TLDR
The Pro/Pro genotype of the p53 codon 72 polymorphism carries a higher risk for gastric cancer in general and is also associated with a much higher risk with EGC than AGC. Expand
Meta-analysis of association between TP53 Arg72Pro polymorphism and bladder cancer risk.
TLDR
The results of the present meta-analysis suggest that the TP53 Arg72 allele is a protective factor and that the Pro/Pro genotype might increase the susceptibility to bladder cancer in Asians. Expand
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TLDR
The TP53 SNP was associated with a significant selection signal for a few climate variables, such as short-wave radiation flux in the winter, but these signals were no longer significant after correction for multiple tests, and these SNPs are unlikely to be under selective pressure driven by these variables. Expand
TP53 Arg72Pro polymorphism is associated with esophageal cancer risk: a meta-analysis.
TLDR
TP53 Arg72 carriers are significantly associated with decreased EC risk, and more well-designed studies are needed to confirm the findings. Expand
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