TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity.

@article{Sammons2015TP53EW,
  title={TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity.},
  author={Morgan A. Sammons and Jiajun Zhu and Adam M. Drake and Shelley L Berger},
  journal={Genome research},
  year={2015},
  volume={25 2},
  pages={179-88}
}
Despite overwhelming evidence that transcriptional activation by TP53 is critical for its tumor suppressive activity, the mechanisms by which TP53 engages the genome in the context of chromatin to activate transcription are not well understood. Using a compendium of novel and existing genome-wide data sets, we examined the relationship between TP53 binding and the dynamics of the local chromatin environment. Our analysis revealed three distinct categories of TP53 binding events that differ… CONTINUE READING