TP53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma among Italian patients

@inproceedings{Vuolo2011TP53AM,
  title={TP53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma among Italian patients},
  author={Valeria Di Vuolo and Luigi Buonaguro and Francesco Izzo and Simona Losito and Gerardo Botti and Franco M. Buonaguro and Maria Lina Tornesello},
  booktitle={Infectious Agents and Cancer},
  year={2011}
}
Single-nucleotide polymorphisms within TP 53 gene (codon 72 exon 4, rs1042522, encoding either arginine or proline) and MDM2 promoter (SNP309; rs2279744), have been independently associated with increased risk of several cancer types. Few studies have analysed the role of these polymorphisms in the development of hepatocellular carcinoma. Genotype… CONTINUE READING