TP53 alterations and colorectal cancer predisposition in south Indian population: A case-control study

@article{Singamsetty2013TP53AA,
  title={TP53 alterations and colorectal cancer predisposition in south Indian population: A case-control study},
  author={Gopi Krishna Singamsetty and Sravanthi Malempati and Srichandana Bhogadhi and Ravinder Kondreddy and Suresh Govatati and Naveen Kumar Tangudu and Sowdamani Govatati and Anil Kumar kuraganti and Manjula Bhanoori and Kondaiah Kassetty},
  journal={Tumor Biology},
  year={2013},
  volume={35},
  pages={2303-2311}
}
The objective of the present study was to investigate the association between TP53 gene single nucleotide polymorphisms (SNPs) and colorectal cancer (CRC) predisposition in south Indian population and to evaluate the role of TP53 expression in the pathophysiology of CRC. A genetic association study was conducted in 103 CRC cases and 107 controls of south Indian origin. We genotyped ten selected TP53 SNPs by polymerase chain reaction-sequencing analysis. Haplotype frequencies for multiple loci… CONTINUE READING
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