TP53 Arg72Pro polymorphism and endometrial cancer risk: a meta-analysis

@article{Jiang2011TP53AP,
  title={TP53 Arg72Pro polymorphism and endometrial cancer risk: a meta-analysis},
  author={Deke Jiang and Lei Yao and Weihua Ren and Wenzhang Wang and Bo Peng and Long Yu},
  journal={Medical Oncology},
  year={2011},
  volume={28},
  pages={1129-1135}
}
Studies investigating the relationship between TP53 Arg72Pro polymorphism and endometrial cancer risk reported conflicting results. To explore a more precise estimate of the effect of this polymorphism on endometrial carcinogenesis, a meta-analysis was performed by searching eligible studies in PubMed. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association for codominant model (Arg/Arg vs. Pro/Pro, Arg/Pro vs. Pro/Pro), dominant model (Arg/Arg + Arg/Pro… 
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References

SHOWING 1-10 OF 42 REFERENCES
P53 polymorphism and lung cancer susceptibility: a pooled analysis of 32 case–control studies
TLDR
The results suggest that the Pro allele at p53 codon 72 is emerging as a low-penetrance susceptibility allele for lung cancer development.
P53 codon 72 polymorphism and gastric cancer: A meta‐analysis of the literature
TLDR
It is suggested that the p53 codon 72 polymorphism may be associated with gastric cancer among Asians, and that difference in genotype distribution may beassociated with the location, stage, and histological differentiation of Gastric cancer.
The p53 Codon 72 Exon 4 BstUI Polymorphism and Endometrial Cancer in Caucasian Women
TLDR
The data did not demonstrate any significant difference in the prevalence of the p53 Arg72Pro genotype between patients and controls, providing evidence that this polymorphism is only weakly associated with the risk of endometrial cancer and prognostic factors in Caucasian women.
Germline polymorphism of p53 codon 72 in gynecological cancer.
P53 codon 72 polymorphism contributes to breast cancer risk: a meta-analysis based on 39 case–control studies
TLDR
A meta-analysis of published studies suggested that p53 codon 72 polymorphism may contribute to susceptibility to breast cancer, especially in Europeans.
p53 and p21 genetic polymorphisms and susceptibility to endometrial cancer.
TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies.
Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer.
Polymorphisms of p53 codon 72 and MDM2 promoter 309 and the risk of endometrial cancer
TLDR
The homozygous variants of wild p53 codon 72 and mutant MDM2 promoter 309 may cooperatively increase the risk of endometrial cancer in a Japanese population.
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