TP53: an oncogene in disguise

@inproceedings{Soussi2015TP53AO,
  title={TP53: an oncogene in disguise},
  author={Thierry Soussi and Klas G Wiman},
  booktitle={Cell Death and Differentiation},
  year={2015}
}
The standard classification used to define the various cancer genes confines tumor protein p53 (TP53) to the role of a tumor suppressor gene. However, it is now an indisputable fact that many p53 mutants act as oncogenic proteins. This statement is based on multiple arguments including the mutation signature of the TP53 gene in human cancer, the various gains-of-function (GOFs) of the different p53 mutants and the heterogeneous phenotypes developed by knock-in mouse strains modeling several… CONTINUE READING
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