TP receptor-mediated vasoconstriction in microperfused afferent arterioles: roles of O(2)(-) and NO.

@article{Schnackenberg2000TPRV,
  title={TP receptor-mediated vasoconstriction in microperfused afferent arterioles: roles of O(2)(-) and NO.},
  author={Christine G. Schnackenberg and William J. Welch and Christopher Stuart Wilcox},
  journal={American journal of physiology. Renal physiology},
  year={2000},
  volume={279 2},
  pages={F302-8}
}
Thromboxane A(2) (TxA(2)) preferentially constricts the renal afferent arteriole. Nitric oxide (NO) modulates vasoconstriction and is rapidly degraded by superoxide radical (O(2)(-)). We investigated the roles of NO and O(2)(-) in rabbit isolated, perfused renal afferent arteriole responses to the TxA(2)/prostaglandin H(2) (TP) receptor agonist U-46,619. U-46,619 (10(-10)-10(-6) M) dose-dependently reduced afferent arteriolar luminal diameter (ED(50) = 7.5 +/- 5.0 nM), which was blocked by the… CONTINUE READING