TOXICOLOGIC EVALUATION OF HUMECTANTS ADDED TO CIGARETTE TOBACCO: 13-WEEK SMOKE INHALATION STUDY OF GLYCERIN AND PROPYLENE GLYCOL IN FISCHER 344 RATS
@article{Heck2002TOXICOLOGICEO, title={TOXICOLOGIC EVALUATION OF HUMECTANTS ADDED TO CIGARETTE TOBACCO: 13-WEEK SMOKE INHALATION STUDY OF GLYCERIN AND PROPYLENE GLYCOL IN FISCHER 344 RATS}, author={J. Daniel Heck and Charles L. Gaworski and Narayanan Rajendran and Robert L. Morrissey}, journal={Inhalation Toxicology}, year={2002}, volume={14}, pages={1135 - 1152} }
Glycerin (CAS no. 56-81-5) and propylene glycol (CAS no. 57-55-6) are commonly used as humectant ingredients in manufactured cigarettes to control and maintain the moisture content of the cut tobacco filler. The potential of these added humectants to affect the toxicity of cigarette smoke was investigated in a subchronic nose-only smoke inhalation study in rats. Filtered test cigarettes were prepared from an American-style tobacco blend containing either glycerin added at 5.1% w/w tobacco…
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References
SHOWING 1-10 OF 30 REFERENCES
Toxicologic evaluation of flavor ingredients added to cigarette tobacco: skin painting bioassay of cigarette smoke condensate in SENCAR mice.
- MedicineToxicology
- 1999
13-week inhalation toxicity study of menthol cigarette smoke.
- Medicine, PsychologyFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- 1997
Evaluation of the potential effects of ingredients added to cigarettes. Part 4: subchronic inhalation toxicity.
- MedicineFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- 2002
Evaluation of the potential effects of ingredients added to cigarettes. Part 1: cigarette design, testing approach, and review of results.
- MedicineFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- 2002
Chronic inhalation of cigarette smoke by F344 rats.
- Medicine, BiologyJournal of the National Cancer Institute
- 1980
Specific-pathogen-free female F344 rats were exposed by inhalation to what was considered a maximal tolerated dose of cigarette smoke and had significantly fewer tumors in the hypophyses, hematopoietic-lymphoid systems, uteri, and ovaries but an increased number of tumor-bearing animals in the respiratory tracts and dermes.
The changing cigarette, 1950-1995.
- MedicineJournal of toxicology and environmental health
- 1997
From a public health perspective, nicotine in the smoke needs to be lowered to a level at which there is no induction of dependence on tobacco, and further needs for reducing the toxicity and carcinogenicity of cigarette smoke are discussed.
Chronic inhalation study in rats, using cigarettes containing different amounts of Cytrel tobacco supplement.
- MedicineToxicology
- 1981
Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice.
- Environmental ScienceAmerican Industrial Hygiene Association journal
- 1977
Con concentration-response relationships were developed by measuring per cent decrease in respiratory rate, indicating upper respiratory tract sensory irritation, and a re-evaluation of the TLVs is suggested.
Morphological methods for evaluation of pulmonary toxicity in animals.
- Medicine
- 1976
This review addresses special methods for investigating various aspects of the pathogenesis of pulmonary lesions likely to be encountered and which are necessary for furthering the understanding of pulmonary pathobiology.