TOX expression decreases with progression of colorectal cancers and is associated with CD4 T-cell density and Fusobacterium nucleatum infection.

@article{Chen2018TOXED,
  title={TOX expression decreases with progression of colorectal cancers and is associated with CD4 T-cell density and Fusobacterium nucleatum infection.},
  author={Ting Chen and Qing Li and Xiaoyan Zhang and Ran Long and Yaxin Wu and Jiao Wu and Xiangsheng Fu},
  journal={Human pathology},
  year={2018},
  volume={79},
  pages={
          93-101
        }
}
Fusobacterium nucleatum in the tumor microenvironment plays an important role in the development of colorectal cancer. The underlying mechanism of action, however, remains to be elucidated. We evaluated the relation of F nucleatum amount to thymocyte selection-associated high-mobility group box (TOX) protein expression and CD4+ T-cell density in 138 human colorectal tissues. TOX expression and CD4+ T-cell density in Fnucleatum-negative tissues were significantly higher compared to those in… CONTINUE READING
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