TOS9 regulates white-opaque switching in Candida albicans.

  title={TOS9 regulates white-opaque switching in Candida albicans.},
  author={Thyagarajan Srikantha and Anthony R. Borneman and Karla J. Daniels and Claude Pujol and Wei Wu and Michael R. Seringhaus and Mark Gerstein and Song Yi and Michael Snyder and David R Soll},
  journal={Eukaryotic cell},
  volume={5 10},
In Candida albicans, the a1-alpha2 complex represses white-opaque switching, as well as mating. Based upon the assumption that the a1-alpha2 corepressor complex binds to the gene that regulates white-opaque switching, a chromatinimmunoprecipitation-microarray analysis strategy was used to identify 52 genes that bound to the complex. One of these genes, TOS9, exhibited an expression pattern consistent with a "master switch gene." TOS9 was only expressed in opaque cells, and its gene product… CONTINUE READING

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Candida albicans, p. 165–201

  • D. R. Soll
  • 2003
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