TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1


Eukaryotic cell cycle progression through G1–S is driven by hormonal and growth-related signals that are transmitted by the target of rapamycin complex 1 (TORC1) pathway. In yeast, inactivation of TORC1 restricts G1–S transition due to the rapid clearance of G1 cyclins (Cln) and the stabilization of the B-type cyclin (Clb) cyclin-dependent kinase (CDK… (More)
DOI: 10.1038/celldisc.2017.12


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