TORC1 controls G1–S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway

  title={TORC1 controls G1–S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway},
  author={Marta Moreno-Torres and Malika Jaquenoud and Claudio De Virgilio},
  booktitle={Nature communications},
The target of rapamycin complex 1 (TORC1) pathway couples nutrient, energy and hormonal signals with eukaryotic cell growth and division. In yeast, TORC1 coordinates growth with G1-S cell cycle progression, also coined as START, by favouring the expression of G1 cyclins that activate cyclin-dependent protein kinases (CDKs) and by destabilizing the CDK inhibitor Sic1. Following TORC1 downregulation by rapamycin treatment or nutrient limitation, clearance of G1 cyclins and C-terminal… CONTINUE READING
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