TORC1 Is Essential for NF1-Associated Malignancies

  title={TORC1 Is Essential for NF1-Associated Malignancies},
  author={Cory M. Johannessen and Bryan W. Johnson and Sybil M. Genther Williams and Annie W.-Y. Chan and Elizabeth E. Reczek and Ryan C. Lynch and Matthew J. Rioth and Andrea I McClatchey and Sandra W. Ryeom and Karen Cichowski},
  journal={Current Biology},
Inactivating mutations in NF1 underlie the prevalent familial cancer syndrome neurofibromatosis type 1 [1]. The NF1-encoded protein is a Ras GTPase-activating protein (RasGAP) [2]. Accordingly, Ras is aberrantly activated in NF1-deficient tumors; however, it is unknown which effector pathways critically function in tumor development. Here we provide in vivo evidence that TORC1/mTOR activity is essential for tumorigenesis. Specifically, we show that the mTOR inhibitor rapamycin potently… CONTINUE READING
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