TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich’s Ataxia

@inproceedings{CalapQuintana2015TORC1IB,
  title={TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich’s Ataxia},
  author={Pablo Calap-Quintana and Sirena Soriano and Jose Vicente Llorens and Ismael Al-Ramahi and Juan Botas and Mar{\'i}a Dolores Molt{\'o} and Mar{\'i}a Jos{\'e} Mart{\'i}nez-Sebasti{\'a}n and Francesc Palau},
  booktitle={PloS one},
  year={2015}
}
Friedreich's ataxia (FRDA), the most common inherited ataxia in the Caucasian population, is a multisystemic disease caused by a significant decrease in the frataxin level. To identify genes capable of modifying the severity of the symptoms of frataxin depletion, we performed a candidate genetic screen in a Drosophila RNAi-based model of FRDA. We found that… CONTINUE READING