TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production

@inproceedings{Philippi2010TORdependentRI,
  title={TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production},
  author={Anja Philippi and Robert Steinbauer and Alarich Reiter and Stephan Fath and Isabelle L{\'e}ger-Silvestre and Philipp Milkereit and Joachim Griesenbeck and Herbert Tschochner},
  booktitle={Nucleic acids research},
  year={2010}
}
Ribosome biogenesis is tightly linked to cellular growth. A crucial step in the regulation of ribosomal RNA (rRNA) gene transcription is the formation of the complex between RNA polymerase I (Pol I) and the Pol I-dependent transcription factor Rrn3p. We found that TOR inactivation leads to proteasome-dependent degradation of Rrn3p and a strong reduction in… CONTINUE READING