Activated mTORC1 signaling: The common driving force of type 2 diabetes and hidradenitis suppurativa.
- Valerio De Vita, Bodo C Melnik
- Journal of the American Academy of Dermatology
- 2018
Highly Influenced
5 Excerpts
TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists
@inproceedings{Blagosklonny2013TORcentricVO,
title={TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists},
author={Mikhail V. Blagosklonny},
booktitle={Cell Death and Disease},
year={2013}
}- Published in Cell Death and Disease 2013
DOI:10.1038/cddis.2013.506
This article is addressed to endocrinologists treating patients with diabetic complications as well as to basic scientists studying an elusive link between diseases and aging. It answers some challenging questions. What is the link between insulin resistance (IR), cellular aging and diseases? Why complications such as retinopathy may paradoxically precede the onset of type II diabetes. Why intensive insulin therapy may initially worsen retinopathy. How nutrient- and insulin-sensing mammalian… CONTINUE READING