TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0.

@article{Pedruzzi2003TORAP,
  title={TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0.},
  author={Ivo Pedruzzi and Fr{\'e}d{\'e}rique Dubouloz and Elisabetta Cameroni and Valeria Wanke and Johnny Roosen and Joris Winderickx and Claudio De Virgilio},
  journal={Molecular cell},
  year={2003},
  volume={12 6},
  pages={
          1607-13
        }
}
The highly conserved Tor kinases (TOR) and the protein kinase A (PKA) pathway regulate cell proliferation in response to growth factors and/or nutrients. In Saccharomyces cerevisiae, loss of either TOR or PKA causes cells to arrest growth early in G(1) and to enter G(0) by mechanisms that are poorly understood. Here we demonstrate that the protein kinase Rim15 is required for entry into G(0) following inactivation of TOR and/or PKA. Induction of Rim15-dependent G(0) traits requires two discrete… CONTINUE READING
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