TOR Regulates the Subcellular Localization of Ime1, a Transcriptional Activator of Meiotic Development in Budding Yeast

@article{Colomina2003TORRT,
  title={TOR Regulates the Subcellular Localization of Ime1, a Transcriptional Activator of Meiotic Development in Budding Yeast},
  author={N. Colomina and Yuhui Liu and M. Aldea and E. Gar{\'i}},
  journal={Molecular and Cellular Biology},
  year={2003},
  volume={23},
  pages={7415 - 7424}
}
ABSTRACT The transcriptional activator Ime1 is a key regulator of meiosis and sporulation in budding yeast. Ime1 is controlled at different levels by nutrients and cell-type signals. Previously, we have proposed that G1 cyclins would transmit nutritional signals to the Ime1 pathway by preventing the accumulation of Ime1 within the nucleus. We show here that nutritional signals regulate the subcellular localization of Ime1 through the TOR pathway. The inactivation of TOR with rapamycin promotes… Expand
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