TOPBP1 missense variant Arg309Cys and breast cancer in a German hospital-based case-control study


The DNA double strand break repair gene TOPBP1 has been suggested as a breast cancer susceptibility gene and a missense variant Arg309Cys was observed at elevated frequency in familial breast cancer cases compared to healthy controls from Finland. We found the Arg309Cys allele at a 13% carrier frequency in a hospital-based series of 1064 German breast… (More)
DOI: 10.1186/1477-5751-9-9


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