TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease

@inproceedings{Bender2013TOM40MM,
  title={TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease},
  author={Andreas Bender and Paula A. Desplats and Brian Spencer and Edward M. Rockenstein and Anthony Adame and Matthias Elstner and Christoph Laub and Sarina K Mueller and Andrew O. Koob and Michael Mante and Emily P Pham and Thomas Klopstock and Eliezer Masliah},
  booktitle={PloS one},
  year={2013}
}
Alpha-synuclein (α-Syn) accumulation/aggregation and mitochondrial dysfunction play prominent roles in the pathology of Parkinson's disease. We have previously shown that postmortem human dopaminergic neurons from PD brains accumulate high levels of mitochondrial DNA (mtDNA) deletions. We now addressed the question, whether alterations in a component of the mitochondrial import machinery--TOM40--might contribute to the mitochondrial dysfunction and damage in PD. For this purpose, we studied… CONTINUE READING

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