TOLL-like receptor ligands stimulate aberrant class switch recombination in early B cell precursors.

@article{Edry2008TOLLlikeRL,
  title={TOLL-like receptor ligands stimulate aberrant class switch recombination in early B cell precursors.},
  author={Efrat Edry and Hilla Azulay-Debby and Doron Melamed},
  journal={International immunology},
  year={2008},
  volume={20 12},
  pages={1575-85}
}
TOLL-like receptor (TLR) ligands stimulate class switch recombination (CSR) in mature B cells. We showed earlier that developing B cells in the bone marrow (BM) express TLR9 and are responsive to CpG DNA. Since CSR is a critical process for synthesis of effector antibodies, we studied the competence of precursor B cells to undergo CSR in response to TLR… CONTINUE READING