TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function.

Abstract

Traf2 and NcK interacting kinase (TNiK) contains serine-threonine kinase and scaffold domains and has been implicated in cell proliferation and glutamate receptor regulation in vitro. Here we report its role in vivo using mice carrying a knock-out mutation. TNiK binds protein complexes in the synapse linking it to the NMDA receptor (NMDAR) via AKAP9. NMDAR… (More)
DOI: 10.1523/JNEUROSCI.2433-12.2012

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