TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins.

@article{Shi2014TNT003AI,
  title={TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins.},
  author={Ju Shi and Eileen L. Rose and Andrew Singh and Sami Hussain and Nancy E. Stagliano and Graham C N Parry and Sandip Panicker},
  journal={Blood},
  year={2014},
  volume={123 26},
  pages={4015-22}
}
Activation of the classical pathway (CP) of complement is often associated with autoimmune disorders in which disease pathology is linked to the presence of an autoantibody. One such disorder is cold agglutinin disease (CAD), an autoimmune hemolytic anemia in which autoantibodies (cold agglutinins) bind to red blood cells (RBCs) at low temperatures. Anemia occurs as a result of autoantibody-mediated CP activation on the surface of the erythrocyte, leading to the deposition of complement… CONTINUE READING
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