TNP-470 inhibits collateralization to complement the anti-tumour effect of hepatic artery ligation.

@article{Mugitani1998TNP470IC,
  title={TNP-470 inhibits collateralization to complement the anti-tumour effect of hepatic artery ligation.},
  author={T. Mugitani and Haruo Taniguchi and Akio Takada and Akio Yamaguchi and Mika Masuyama and Masakazu Hoshima and Tomoyuki Takahashi},
  journal={British Journal of Cancer},
  year={1998},
  volume={77},
  pages={638 - 642}
}
We examined hepatic artery ligation combined with an angiogenesis inhibitor, TNP-470, in the treatment of VX2 tumour inoculated into the liver of rabbits. Effects on tumour growth were correlated with arterial collateral development in this system. Three treatment methods were compared: (1) the left hepatic artery was ligated at the liver hilum (ligation group); (2) TNP-470 (40 mg per body) was infused continuously for 7 days via the common hepatic artery (TNP group); (3) the left hepatic… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Efficacy of angiogenesis inhibitor, TNP-470, in Xenotransplanted human colorectal cancer with high metastatic potential

M Kusaka, K Sudo, +3 authors D Ingber
Cancer 77: • 1996

Prevention of hepatic metastasis of human colon cancer

T Tanaka, H Konno, I Matsuda, S Nakamura, S Baba
1995

Antitumor effects of angiogenesis inhibitor TNP-470 in rabbits bearing VX-2 carcinoma by arterial administration of microspheres and oil solution

H Konno, T Tanaka, +3 authors S Baba
J Pharmacol Exp Therapeut • 1992

The use of degradable starch microspheres with intra - arterial chemotherapy for the treatment of primary and secondary liver tumour - results of a phase III clinical trial

T Taguchi, N Ogawa, B Bunke, B Nilsson
Reg Cancer Treatment • 1992

with high metastatic potential

M Kusaka, K Sudo, +4 authors J Folkman
1991

Similar Papers

Loading similar papers…