TNP-470 Inhibits 7,12-Dimethylbenz[a]anthracene–Induced Mammary Tumor Formation When Administered Before the Formation of Carcinoma In Situ but Is Not Additive with Tamoxifen

@article{Heffelfinger2003TNP470I7,
  title={TNP-470 Inhibits 7,12-Dimethylbenz[a]anthracene–Induced Mammary Tumor Formation When Administered Before the Formation of Carcinoma In Situ but Is Not Additive with Tamoxifen},
  author={Sue C. Heffelfinger and Robin B Gear and Joanne Kraenzle Schneider and Kathy Ladow and Mei Yan and Fengxian Lu and Amy L. Pyle and David Warshawsky},
  journal={Laboratory Investigation},
  year={2003},
  volume={83},
  pages={1001-1011}
}
In many women pathologic lesions, such as hyperplasia and carcinoma in situ, precede invasive breast cancer. We have shown that tissue vascularity increases with histologic progression to invasive disease. Similarly, in the well-characterized 7,12-dimethylbenz[a]anthracene (DMBA) model of mammary tumorigenesis, preinvasive lesions exhibit increased… CONTINUE READING