TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

@inproceedings{Ghoshal2016TNPN,
  title={TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway},
  author={Sarbani Ghoshal and Qingzhang Zhu and Alice Asteian and Hua Lin and Haifei Xu and Glen J. Ernst and James C Barrow and Baoji Xu and Michael D. Cameron and Theodore M Kamenecka and Anutosh Chakraborty},
  booktitle={Molecular metabolism},
  year={2016}
}
OBJECTIVE Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration. Therefore, extensive research is ongoing to identify novel pathways that can be targeted in obesity/T2D. Deletion of the inositol pyrophosphate (5-IP7) biosynthetic enzyme, inositol hexakisphosphate kinase-1 (IP6K1), protects mice from high fat diet (HFD) induced obesity (DIO) and insulin resistance. Yet, whether this… CONTINUE READING
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