TNFalpha potentiates IFNgamma-induced cell death in oligodendrocyte progenitors.

  title={TNFalpha potentiates IFNgamma-induced cell death in oligodendrocyte progenitors.},
  author={Tara Andrews and Pinliang Zhang and Narayan R. Bhat},
  journal={Journal of neuroscience research},
  volume={54 5},
Oligodendrocytes in multiple sclerosis brain may be under a direct attack by proinflammatory cytokines, particularly tumor necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma). In this study, we have examined the in vitro cytotoxic effects of the two cytokines, individually and in combination, on oligodendrocyte lineage cells using morphological criteria, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide reduction assay (MTT), terminal deoxynucleotide transferase… CONTINUE READING
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