TNFalpha-mediated extracellular matrix remodeling is required for multiple division cycles in rat hepatocytes.

@article{Srandour2005TNFalphamediatedEM,
  title={TNFalpha-mediated extracellular matrix remodeling is required for multiple division cycles in rat hepatocytes.},
  author={Anne-Laure S{\'e}randour and Pascal Loyer and Delphine Garnier and Brice Courselaud and Nathalie Th{\'e}ret and Denise Glaise and Christiane Guguen-Guillouzo and Anne Corlu},
  journal={Hepatology},
  year={2005},
  volume={41 3},
  pages={478-86}
}
During liver regeneration, hepatocytes proliferate under the control of both proinflammatory cytokines such as tumor necrosis factor alpha (TNFalpha) and growth factors, in parallel to extracellular matrix remodeling. This study investigated mechanisms by which mitogen and extracellular matrix signals are linked for inducing proliferation of differentiated hepatocytes. The authors used adult rat hepatocytes in coculture with liver biliary cells, because cells are stably differentiated for… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Similar Papers

Loading similar papers…