TNFalpha induces HIF-1alpha expression through activation of IKKbeta.

@article{Kuo2009TNFalphaIH,
  title={TNFalpha induces HIF-1alpha expression through activation of IKKbeta.},
  author={Hsu-Ping Kuo and Dung-Fang Lee and Weiya Xia and Yongkun Wei and M -C Hung},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={389 4},
  pages={640-4}
}
The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is regulated by oxygen availability as well as various inflammatory mediators, including tumor necrosis factor alpha (TNFalpha). Early work suggested that the phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling pathways are involved in TNFalpha-mediated HIF-1alpha accumulation and activation under normoxic conditions. Here, we provide evidence showing that IkappaB kinase beta (IKKbeta… CONTINUE READING

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