TNFalpha-induced glutathione depletion lies downstream of cPLA(2) in L929 cells.


Both glutathione (GSH) depletion and arachidonic acid (AA) generation have been shown to regulate sphingomyelin (SM) hydrolysis and are known components in tumor necrosis factor alpha (TNFalpha)-induced cell death. In addition, both have hypothesized direct roles in activation of N-sphingomyelinase (SMase); however, it is not known whether these are… (More)


  • Presentations referencing similar topics