TNFalpha-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells.

@article{Inoue2004TNFalphainducedAE,
  title={TNFalpha-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells.},
  author={Koichi Inoue and Takeru Zama and Takahiro Kamimoto and Ryoko Aoki and Yasuo Ikeda and Hiroshi Kimura and Masatoshi Hagiwara},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2004},
  volume={9 1},
  pages={59-70}
}
ATF3 (Activating transcription factor 3), a member of the CREB/ATF family, can be induced by stress and growth factors in mammalian cells, and is thought to play an important role in the cardiovascular system. However, little is currently known about how the induction of ATF3 is regulated, except that the JNK pathway is involved. Here, we investigated the differential roles of the MAPK pathways involved in TNFalpha (tumour necrosis factor alpha)-induced ATF3 expression in vascular endothelial… CONTINUE READING

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