TNFalpha and IL-6 are mediators in the blistering process of pemphigus.


BACKGROUND Pemphigus is an autoimmune disease characterized by intraepidermal blisters induced by pemphigus IgG. In addition to autoantibodies, molecular mechanisms involved in acantholysis remain largely unknown. For this reason, we address a possible role of the inflammatory cytokines IL-6 and TNFalpha in pemphigus lesions. METHODS Sixteen biopsies from… (More)