TNFSF15 Modulates Neovascularization and Inflammation


Tumor necrosis factor superfamily-15 (TNFSF15; also known as VEGI or TL1A) is a unique cytokine that functions in the modulation of vascular homeostasis and inflammation. TNFSF15 is expressed abundantly in established vasculature but is down-regulated at sites of neovascularization such as in cancers and wounds. TNFSF15 inhibits endothelial cell proliferation and endothelial progenitor cell differentiation. Additionally, TNFSF15 stimulates T cell activation, Th1 cytokine production, and dendritic cell maturation. Some of the functions of TNFSF15 are mediated by death receptor-3. We review the experimental evidences on TNFSF15 activities in angiogenesis, vasculogenesis, inflammation, and immune system mobilization.

DOI: 10.1007/s12307-012-0117-8

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@article{Zhang2012TNFSF15MN, title={TNFSF15 Modulates Neovascularization and Inflammation}, author={Zhisong Zhang and Lu-Yuan Li}, journal={Cancer Microenvironment}, year={2012}, volume={5}, pages={237-247} }