TNFSF14 coordinately enhances CXCL10 and CXCL11 productions from IFN-gamma-stimulated human gingival fibroblasts.

@article{Hosokawa2010TNFSF14CE,
  title={TNFSF14 coordinately enhances CXCL10 and CXCL11 productions from IFN-gamma-stimulated human gingival fibroblasts.},
  author={Yoshitaka Hosokawa and Ikuko Hosokawa and Kazumi Ozaki and Hideaki Nakae and Takashi Matsuo},
  journal={Molecular immunology},
  year={2010},
  volume={47 4},
  pages={666-70}
}
TNFSF14 is involved in the pathogenesis of some inflammatory diseases such as arthritis. CXCL10 and CXCL11 recruit Th1 cells, and the productions of these chemokines are related to the exacerbation of some inflammatory diseases including arthritis and periodontal disease. We examined in vitro effects of TNFSF14 on IFN-gamma-induced CXCL10 and CXCL11 production in human gingival fibroblasts (HGFs). HGFs constitutively expressed TNFSF14 receptors, LTbetaR and HVEM. TNFSF14 enhanced IFN-gamma… CONTINUE READING

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