TNFRSF1A mutations and autoinflammatory syndromes.

  title={TNFRSF1A mutations and autoinflammatory syndromes.},
  author={J{\'e}r{\^o}me Galon and Ivona Aksentijevich and Michael F McDermott and John J O'Shea and Daniel L. Kastner},
  journal={Current opinion in immunology},
  volume={12 4},
The autoinflammatory syndromes are systemic disorders characterized by apparently unprovoked inflammation in the absence of high-titer autoantibodies or antigen-specific T lymphocytes. One such illness, TNF-receptor-associated periodic syndrome (TRAPS), presents with prolonged attacks of fever and severe localized inflammation. TRAPS is caused by dominantly inherited mutations in TNFRSF1A (formerly termed TNFR1), the gene encoding the 55 kDa TNF receptor. All known mutations affect the first… CONTINUE READING
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