TNF2, a polymorphism of the tumour necrosis-alpha gene promoter, is a component of the celiac disease major histocompatibility complex haplotype.

@article{McManus1996TNF2AP,
  title={TNF2, a polymorphism of the tumour necrosis-alpha gene promoter, is a component of the celiac disease major histocompatibility complex haplotype.},
  author={Ross McManus and Anthony Gerard Wilson and J D Mansfield and Donald George Weir and Gordon W. Duff and Dermot Kelleher},
  journal={European journal of immunology},
  year={1996},
  volume={26 9},
  pages={2113-8}
}
Celiac disease (CD) is an immune disease triggered by the cereal antigen gliadin, resulting in villous atrophy in the small intestine. Susceptibility to the development of CD is strongly influenced by genes in the major histocompatibility complex, in particular alleles of the DQ genes in the class II region. However recent evidence has suggested that the major histocompatibility complex (MHC) class III region may be linked to celiac disease independently of the class II region. Among the genes… CONTINUE READING

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