TNF tolerance and cytotoxicity in the liver: the role of interleukin-1β, inducible nitric oxide-synthase and heme oxygenase-1 in D-galactosamine-sensitized mice

@article{Sass2002TNFTA,
  title={TNF tolerance and cytotoxicity in the liver: the role of interleukin-1β, inducible nitric oxide-synthase and heme oxygenase-1 in D-galactosamine-sensitized mice},
  author={Gabriele Sass and Kerstin Koerber and Gisa Tiegs},
  journal={Inflammation Research},
  year={2002},
  volume={51},
  pages={229-235}
}
Objective and design: Pretreatment with tumor necrosis factor (TNF)- α induces tolerance towards itself in experimental liver injury.¶Material and treatment: To study mechanisms of TNF tolerance we used knockout mice for either TNF-receptor-2 (TNFR-2), inducible nitric oxide (NO)-synthase (iNOS) or caspase-1 (ICE) or inhibited heme oxygenase-1 (HO-1) by treatment with zinc-protoporphyrin 9. Liver damage was induced by administration of TNF to mice sensitized with d-galactosamine (GalN… CONTINUE READING

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