TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

Abstract

The role of tumor necrosis factor (TNF) as an immune mediator has long been appreciated but its function in the brain is still unclear. TNF receptor 1 (TNFR1) is expressed in most cell types, and can be activated by binding of either soluble TNF (solTNF) or transmembrane TNF (tmTNF), with a preference for solTNF; whereas TNFR2 is expressed primarily by… (More)
DOI: 10.1186/1742-2094-5-45

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