TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality.

@article{Mizoguchi2008TNFRT,
  title={TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality.},
  author={Emiko Mizoguchi and Yuriko Hachiya and Mayumi Kawada and Katsuya Nagatani and Atsuhiro Ogawa and Ken Sugimoto and Atsushi Mizoguchi and Daniel K. Podolsky},
  journal={Gastroenterology},
  year={2008},
  volume={134 2},
  pages={470-80}
}
BACKGROUND & AIMS Ligation of tumor necrosis factor (TNF) receptors (TNFRs) with TNF plays a critical role in the pathogenesis of human inflammatory bowel disease (IBD). However, it remains unclear which cell types activated through TNFR-associated signaling cascades are involved in the pathogenesis of colitis. METHODS Recombination activating gene-1 (RAG) knockout (KO) (no T or B cells)-based TNFR double and triple KO mice were generated. Bone marrow (BM) chimera mice in which BM-derived… CONTINUE READING