TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1.

Abstract

Tumor necrosis factor (TNF) mediates its biological effects by binding to two distinct but homologous receptor molecules. The type 1 receptor (TNF-R1) has been shown to be essential and sufficient for most cellular responses to soluble TNF. In contrast, only limited data exist concerning the role of the type 2 receptor (TNF-R2) in TNF responses, both in vitro and in vivo. Here, we demonstrate by the use of thymocytes from TNF-R-deficient mice that the TNF-R2-dependent enhancement of proliferation and secretion of granulocyte-macrophage colony-stimulating factor is in fact mediated by TNF-R2 on its own, independent of co-expression and/or stimulation of TNF-R1.

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@article{Grell1998TNFRT, title={TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1.}, author={Matthias Grell and Florian M Becke and Harald Wajant and Daniela N M{\"a}nnel and Peter Scheurich}, journal={European journal of immunology}, year={1998}, volume={28 1}, pages={257-63} }