TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses.

@article{Wang2013TNFlikeL1,
  title={TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses.},
  author={Xuehai Wang and Yan Hu and Tania Charpentier and Alain Lamarre and Shijie Qi and Jiang-ping Wu and Hongyu Luo},
  journal={Journal of immunology},
  year={2013},
  volume={191 11},
  pages={
          5420-9
        }
}
TNF-like ligand 1A (TL1A), also known as TNFSF15, is a member of the TNF superfamily. Its known receptor is death receptor 3 (DR3). In humans, TL1A also binds to a secreted TNF family member called decoy receptor 3, which interferes with the interaction between TL1A and DR3. TL1A/DR3 signal has been implicated in several autoimmune diseases in animal models as well as in clinical conditions. We generated TL1A gene knockout (KO) mice to assess its role in collagen-induced arthritis (CIA), a… CONTINUE READING
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