TNF-induced anorexia and learned food aversions are attenuated by area postrema lesions.

@article{Bernstein1991TNFinducedAA,
  title={TNF-induced anorexia and learned food aversions are attenuated by area postrema lesions.},
  author={I. Leonard Bernstein and Edwin Michael Taylor and Kathy L. Bentson},
  journal={The American journal of physiology},
  year={1991},
  volume={260 5 Pt 2},
  pages={
          R906-10
        }
}
Tumor necrosis factor (TNF) or cachectin has been proposed as an important mediator of cancer anorexia and cachexia. The present studies examined the extent to which TNF administration generates symptoms similar to those produced by tumor growth. Like the growth of certain tumors, TNF administration was found to be associated with the development of strong aversions to a novel diet. Area postrema lesions were found to significantly attenuate the effects of TNF on intake of a novel diet, a… CONTINUE READING
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