TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death.

@article{Kim2007TNFinducedAO,
  title={TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death.},
  author={You-sun Kim and Michael J. Morgan and Swati Choksi and Zheng-gang Liu},
  journal={Molecular cell},
  year={2007},
  volume={26 5},
  pages={675-87}
}
Tumor necrosis factor (TNF) is an important cytokine in immunity and inflammation and induces many cellular responses, including apoptosis and necrosis. TNF signaling enables the generation of superoxide in phagocytic and vascular cells through the activation of the NADPH oxidase Nox2/gp91. Here we show that TNF also activates the Nox1 NADPH oxidase in mouse fibroblasts when cells undergo necrosis. TNF treatment induces the formation of a signaling complex containing TRADD, RIP1, Nox1, and the… CONTINUE READING
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