TNF dose reduction in isolated limb perfusion.

  title={TNF dose reduction in isolated limb perfusion.},
  author={Dirk Jan Gr{\"u}nhagen and J H W de Wilt and Albertus N. van Geel and Wilfried J. Graveland and Cornelis Verhoef and A. M. M. Eggermont},
  journal={European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology},
  volume={31 9},
AIMS Isolated limb perfusion with TNF and melphalan (TM-ILP) is highly effective in the local treatment of advanced sarcoma and melanoma of the limb. The optimal dose of TNF for this procedure is not well established. The aim of this study was to assess the efficacy and toxicity of TM-ILPs with reduced TNF dose. METHOD Largest single institution prospective database on TNF-based ILP. Out of 339 TM-ILPs performed between 1991 and 2003, 64 procedures were performed with reduced TNF dose (<3 mg… CONTINUE READING