TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases

  title={TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases},
  author={Marc Feldmann and Ravinder Nath Maini},
  journal={Nature Medicine},
Nat. Med. 9, 1245–1250 (2003) A callout for Figure 3 should have been inserted on p. 1248. The last sentence of the first paragraph of column 3 should read, “...the relative rarity of sustained remission of disease (Fig. 3).” We regret the error. 
TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease
Evaluation of 112,152 medical records indicates that benign prostatic hyperplasia (BPH) prevalence is significantly higher among patients with AI diseases and that reducing inflammation with a therapeutic agent can suppress BPH.
The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19
Analyzing glycans cleaved from a biotherapeutic protein using ultrahigh-resolution ion mobility spectrometry together with cryogenic ion spectroscopy.
This work proposes a multidimensional approach for monitoring released glycans that combines ultrahigh-resolution ion mobility spectrometry (IMS) and cryogenic vibrational spectroscopy, and demonstrates this technique by characterizing four N-glycans cleaved from the therapeutic fusion protein etanercept.
Adipose-Derived Molecules–Untouched Horizons in Alzheimer’s Disease Biology
Understanding the role of adipose-derived molecules in the development of AD, especially in the induction of autophagy, would open up new avenues in devising strategies for the treatment of AD.
Theranostic nanoparticles for future personalized medicine.
  • J. Ryu, Sangmin Lee, I. Kwon
  • Biology, Medicine
    Journal of controlled release : official journal of the Controlled Release Society
  • 2014
Design and Optimisation of Bioactive Cyclic Peptides: Generation of a Down-Regulator of TNF Secretion
Putting F, R and S amino acids into a short cyclic peptide scaffold is extended, and the optimal configuration required to overcome the problems of conformational instability, and give rise to molecules which have potential as therapeutic agents in human disease, such as rheumatoid arthritis.
The management of patients with malignant hyperthermia in the oral and maxillofacial surgery setting and the recent advances in the field of MH are presented.
Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ.
It is shown that DAZ cannot bind simultaneously to DAZAP1 and PABP, and it is suggested that the phosphorylation-induced dissociation of DAZ and DAZap1 may allow the former to stimulate translation by interacting with P ABP.