TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1

@inproceedings{Moujalled2013TNFCA,
  title={TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1},
  author={Donia M. Moujalled and Wendy Diane Cook and Toru Okamoto and James M Murphy and Kate E Lawlor and James Edward Vince and David L. Vaux},
  booktitle={Cell Death and Disease},
  year={2013}
}
Ligation of tumor necrosis factor receptor 1 (TNFR1) can cause cell death by caspase 8 or receptor-interacting protein kinase 1 (RIPK1)- and RIPK3-dependent mechanisms. It has been assumed that because RIPK1 bears a death domain (DD), but RIPK3 does not, RIPK1 is necessary for recruitment of RIPK3 into signaling and death-inducing complexes. To test this assumption, we expressed elevated levels of RIPK3 in murine embryonic fibroblasts (MEFs) from wild-type (WT) and gene-deleted mice, and… CONTINUE READING

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