TNF binding protein prevents hyperlactatemia and inactivation of PDH complex in skeletal muscle during sepsis.

@article{Vary1998TNFBP,
  title={TNF binding protein prevents hyperlactatemia and inactivation of PDH complex in skeletal muscle during sepsis.},
  author={Thomas C. Vary and Stacy Hazen and George O. Maish and Robert N Cooney},
  journal={The Journal of surgical research},
  year={1998},
  volume={80 1},
  pages={44-51}
}
BACKGROUND Hyperlactatemia is a metabolic complication of hypermetabolic, hyperdynamic sepsis. An important mechanism responsible for elevating plasma lactate concentrations in sepsis is altered regulation of the pyruvate dehydrogenase complex (PDH) in skeletal muscle. We investigated the ability of a specific tumor necrosis factor binding protein, TNFbp, to modulate lactate concentrations and skeletal muscle PDH activity in a rodent model of chronic abdominal sepsis. MATERIALS AND METHODS We… CONTINUE READING

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