TNF and receptors in organ-specific autoimmune disease: multi-layered functioning mirrored in animal models.

@article{Kassiotis2001TNFAR,
  title={TNF and receptors in organ-specific autoimmune disease: multi-layered functioning mirrored in animal models.},
  author={George Kassiotis and George Kollias},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={107 12},
  pages={1507-8}
}
tis (RA) is proving efficacious for a large number of patients (1). Despite this exciting outcome, however, there is still little knowledge of the actual biology that is targeted by this therapy. Potential effector activities of TNF that may be relevant to the observed therapeutic impact are numerous and include its well-known proinflammatory activities, the potential activating effects it may have on important cell types (e.g., macrophages or synoviocytes), and its functions in shaping innate… CONTINUE READING
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