TNF-alpha signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K.

@article{Perez2000TNFalphaSA,
  title={TNF-alpha signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K.},
  author={Denise I. Perez and Eileen White},
  journal={Molecular cell},
  year={2000},
  volume={6 1},
  pages={
          53-63
        }
}
The adenovirus E1B 19K gene product is an inhibitor of apoptosis induced by tumor necrosis factor-alpha (TNF-alpha) during viral infection. We report that E1B 19K inhibited neither caspase-8 activation nor caspase-8-dependent Bid cleavage by TNF-alpha. Rather, TNF-alpha induced a tBid-dependent conformational change in Bax that allowed an interaction between E1B 19K and conformationally altered Bax, which caused inhibition of cytochrome c release and caspase-9 activation. E1B 19K expression… CONTINUE READING
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